The bye week was much needed for the banged-up San Francisco 49ers, but will it be enough for this group to salvage part of its season? The Los Angeles Rams have locked down on opponents most of the season and the 49ers are lacking offensive firepower right now. Los Angeles has a pair of fantastic receivers who will test the San Francisco secondary, and make like difficult for the 49ers. 49ers vs. Rams Betting Odds Any chance the 49ers have in this game hinges on the injuries to the offensive skill positions. San Francisco will certainly be without Jimmy Garoppolo and George Kittle, but the question will be who will join Nick Mullens in the backfield as the running back and how Deebo Samuels’ ankle heals. The 49ers are very thin at running back right now and if Samuels is out again this week, it will limit Mullens’ passing options. San Francisco allowed at least 27 points in each of its three games before the bye week as the injuries on defense began to catch up with the team’s performance. If the 49ers are limited to backups in the backfield and receiving corps then the defense will need to step up against this Rams offense. However, we’ve seen how well teams have marched down the field to score against San Francisco recently, and the Rams rank fifth in yards gained per game. Los Angeles scored 27 points in its win over Tampa Bay last week, the most it has scored in the last five games. Whereas the Rams do gain a lot of yards, they don’t convert those yards into points often enough, ranking 26th in the league by scoring on just 36 percent of their drives. The defense, though, is a legit and should overpower the 49ers’ depleted offensive weapons because San Francisco will not be near enough to 100 percent. It’s the type of game that should benefit Aaron Donald and his pass-rushing ability to put pressure on Mullens. Offensively, the Rams might not be able to get the rushing attack going again as San Francisco has still committed to slowing down the ground game of its opponents. That will mean plenty of targets for Cooper Kupp and Robert Woods, both of whom had monster games last week against the Buccaneers. The 49ers have looked worse against the pass heading into the bye week, and Jared Goff has enough weapons to take advantage of those weaknesses. This will be a battle of the defenses, and it is clear that the Rams’ unit has been playing much better recently than the 49ers defense. This will be a low-scoring game, so the overall over/under of 45.5 points seems a but high. I think these two teams will struggle to put up 40 combined points in this game given the offensive struggles to score points recently. San Francisco has scored a combined 30 points in its last two games as the skill players were ravaged by injuries. The Rams just don’t convert their yards into points enough for me to believe it can do it a lot against the 49ers. So I’ll take under 39.5 total points for +200 odds at the NFL betting sites in New Jersey. Rams to win The Rams are only favored by a touchdown in this game, which presents a fantastic chance at value. Los Angeles isn’t the best offense in the league, but the duo of Kupp and Woods proved last week just how good they can be in this offense. The Rams know how to rack up yards and San Francisco’s injury situation makes me believe the Rams can score plenty of points this week. But what really seals the deal for me is the mismatch between the 49ers depleted offense and a suffocating Rams defense. I think the Rams can easily win this game by three scores, so I’ll bet Los Angeles laying 16.5 points for +250 odds at the New Jersey online sports betting sites.