The San Francisco 49ers are in trouble on offense without Jimmy Garoppolo as Nick Mullens has struggled to be consistent. Those scoring woes will be challenged by the Miami Dolphins, who should have gained some confidence after a tight game with Seattle last week at home. The trip to the West Coast and a strong 49ers defense will be the difference, but Miami will make it tough on San Francisco, for sure. Miami Dolphins vs. San Francisco 49ers Betting Odds There were a lot of positives for Miami’s offense last week against Seattle as the Dolphins were able to stay pretty close to the Seahawks for most of the game. Ryan Fitzpatrick threw for more than 300 yards, but his two interceptions both led to touchdowns for the Seahawks on short fields. The San Francisco defense is far better than Seattle’s unit, but the 49ers’ attack is also far worse than the Seahawks’ offense. Fitzpatrick will need to be more careful with his throws against the 49ers, and Miami will need to deal with the pass rush better. However, the Dolphins defense has a chance to make some plays like it did last week against Seattle when Miami sacked Russell Wilson twice and intercepted him once. The Dolphins will have the chance to create extra possessions with takeaways, and they have a good chance at applying pressure on the 49ers quarterback. It becomes a question of whether or not Fitzpatrick can protect the ball and avoid costly turnovers. San Francisco’s main issue right now is its offense, which sputtered last week against the Eagles. I’m not sure what it says about the 49ers that their best success on offense this season came in New York against the Jets and Giants, but last week was a step back for Nick Mullens as he threw two interceptions and was sacked four times. The weapons are there for the 49ers in the passing game, but Mullens’ struggles don’t give me a lot of confidence. The team could start C.J. Beathard instead, but he was 1-9 with 12 touchdowns and 13 interceptions combined in 2017 and 2018 when replacing Garoppolo as a starter. The 49ers could really use some help on the injury front in the running game, but it’s unlikely Raheem Mostert will be ready and/or effective for Sunday’s game. So the 49ers will need to rely on their defense to slow down Fitzpatrick and force him into mistakes that will give San Francisco extra possessions. The New Jersey online sports betting sites have made the points wager very easy on me. The over/under is set at 49.5 points, and it’s hard for me to envision these two teams hitting that number this week. Miami will struggle against San Francisco’s depleted but still tough defense, and the 49ers offense is still a mess. This feels like it will be very similar to last week’s game for San Francisco when neither team really asserted control over the game and the Eagles happened to have scored more points at the end. The odds on the points total aren’t spectacular, but I’ll still take the under 49.5 total points at -115 odds. 49ers to win I am very uneasy about the 8.5-point spread in the 49ers’ favor because there are still a lot of questions about that offense. Miami’s weakness is defending the pass, but San Francisco’s passing game has suffered since Jimmy Garoppolo’s injury. The 49ers rely heavily on the running game, which should be able to have some success against the Dolphins’ defense, but might not be enough to pull out a big victory. With the NFL betting sites in New Jersey not offering any alternate spreads, I’m instead going to just take the safe route and pick San Francisco to win by 13 points or fewer at +140 odds.