The Philadelphia Eagles are in tailspin right now so the last thing they needed was a cross-country trip to face the defending NFC champions. The San Francisco 49ers have been hit hard with injuries the past two weeks, but it hasn’t stopped them from taking care of business in New York. San Francisco has faced far more adversity this season than Philadelphia, and it has handled is far better as well than the Eagles. Unless something magically changes for the Eagles overnight, Philadelphia enters the game like a wounded bird, and the 49ers should roll with ease. Philadelphia Eagles vs. San Francisco 49ers Betting Odds The Philadelphia Eagles are a shell of the team that won the Super Bowl just three seasons ago. Carson Wentz is struggling in a big way having thrown twice as many interceptions (six) and touchdowns (three) through three games. He’s completing less than 60 percent of his passes and he hasn’t thrown for 250 yards in consecutive weeks. Miles Sanders has been productive the past two weeks out of the backfield, but it has not been nearly enough to help the Eagles win any games. The 23 points Philadelphia scored last week against Cincinnati were the most it has scored all season, and it still took a touchdown with 30 seconds left to tie the game against the worst team in football last season. The Eagles’ defense hasn’t been terrible, but average isn’t good enough when the offense is bordering on being worse than mediocre. I will concede that the Jets and Giants are not the toughest opponents, but San Francisco has looked mighty impressive the last two weeks after a shocking loss to Arizona to open the season. Whether it’s been Jimmy Garoppolo or Nick Mullens under center, the 49ers offense has put up 30 points in back-to-back weeks while just overwhelming opposing offenses with reserve defensive players at several positions. The running game has been effective no matter who is carrying the ball and Mullens looked extremely comfortable throwing the ball last week against the Giants. The 49ers have been devastated by major injuries to several key players, but they have continued to roll along on both sides of the ball, showing off the depth and talent that allowed them to reach the Super Bowl last season. My NFL betting predictions for this game focus on the ineptitude of the Eagles offense and how that will affect the total point totals in this game. The over/under is set at 45 points, but more surprisingly is that the Eagles’ point total was set at 18.5 points. The easy bet in this case is to take the under at -108 odds because this broken team has barely scored 17 in the first three weeks and this is by far the best defense Philadelphia has faced this season. San Francisco’s injuries means it likely won’t put up a lot of points, either, but it has a bigger leeway given how little trust I have in Wentz and the Eagles to score. I’ll trim the total points total down to 42.5 and take the under at +130 odds. San Francisco 49ers to win The current form of the Eagles offense stands no chance at putting up many points against the 49ers defense. San Francisco overwhelmed the Jets and Giants the past two weeks, and it should do the same to a flimsy Eagles offensive line. The constant pressure on Wentz will force mistakes and the 49ers have been great at capitalizing on those miscues. The 49ers should actually be getting healthier on offense, too, so the seven-point spread set by the New Jersey online sports betting sites might not be enough. I was tempted to almost double the spread on the alternate lines, but the value wasn’t there, so I’ll settle in at San Francisco laying 10.5 points instead. With +135 odds at the NFL betting sites in New Jersey, I’ll bet on the 49ers laying those 10.5 points.