Week 13 is here and brings us a ton of great matchups, highlighted by a solid slate of division battles on Thanksgiving. The holiday is one of the highlights of the NFL season, and this season is no different.
Our experts at USAlegalbetting.com have been studying each team over the first few weeks, and they are sharing their favorite eight bets heading into Week 13.
Below, we will share their picks, along with odds and insights, to help you win big at NFL betting sites this weekend.
Odds provided by Fanduel
| Games | Away Odds | Home Odds | Info (EST) |
| Seahawks @ Cowboys | +350 | -450 |
AT&T Stadium, Thursday 8:15 PM |
| Chargers @ Patriots | -250 | +205 |
Gillete Stadium, Sunday 1:00 PM |
| Cardinals @ Steelers | +210 | -255 |
Acrisure Stadium, Sunday 1:00 PM |
| Broncos @ Texans | +152 | -180 |
NRG Stadium, Sunday 1:00 PM |
| Lions @ Saints | -200 | +168 |
Caesars Superdome, Sunday 1:00 PM |
| Colts @ Titans | -116 | -102 |
Nissan Stadium, 1:00 PM |
| Panthers @ Titans | +162 | -194 |
Nissan Stadium, Sunday 1:00 PM |
| Falcons @ Jets | -146 | +124 |
MetLife Stadium, Sunday 1:00 PM |
| Dolphins @ Commanders | -460 | +360 |
FedEx, Sunday 1:00 PM |
| Panthers @ Buccaneers | +205 | -250 |
Raymond James Stadium, Sunday 4:05PM |
| 49ers @ Eagles | -152 | +128 |
Lincoln Financial Stadium, Sunday 4:25 PM |
| Browns @ Rams | +148 | -178 |
SoFi, Sunday 4:25 PM |
| Chiefs @ Packers | -430 | +340 |
Allegiant Stadium, Sunday 8:20 PM |
| Bengals @ Jaguars | +315 | -400 | EverBank Stadium, Monday 8:15 PM |
The Seahawks have lost their last two games and will be in store for another against the Cowboys on Sunday. Their defense seems to get worse each week, and Geno Smith is nowhere near the player he was in 2022. He is taking more sacks and has thrown for under 181 yards in two of their previous four games. He still shows some skill against bad defenses, but that is not what he will face on Sunday.
The Cowboys are one of the hottest teams in football, winning four of their last five games. They are gaining the league's fifth most yards per game (377.6), and the defense allows the third least (276.3). They have several starts playing at a Pro Bowl level on both sides of the ball, and Seattle doesn’t have the talent to match it. That will lead to the Cowboys’ fourth straight blowout win on Thursday Night Football.
Seahawks injury report
Cowboys injury report
| Bookmaker | Pick | Odds |
 | Cowboys -8.5 | -110 |
 | Cowboys ML | -450 |
 | Under 47.5 | -110 |
The Colts come into Sunday’s game riding a three-game winning streak. While they lost running back Jonathan Taylor to a thumb injury, backup Zach Moss thrived as the starter while Taylor sat out the beginning of the season. He will have no problem carving up the Titans, once again Gardner Minshew, as he manages the passing attack. The Colts defense isn’t great, but they have allowed just 39 points over their last three games. Considering how bad the Titans' offense has been, they should have no problem putting together another solid outing.
The Titans broke a three-game losing streak last week but came against the 1-10 Panthers. Their offense again struggled with Will Levis at quarterback, though the rookie’s accuracy was improved. Tennessee was crushed by the Colts back in Week 5, and they have gotten far worse since then. While the Colts aren’t a great team, they have looked far better than the Titans over the last two months.
Colts injury report
Titans injury report
| Bookmaker | Pick | Odds |
| Colts -1.5 | -105 |
| Cowboys ML | -120 |
| Over 42.5 | -110 |
A matchup against the Saints is exactly what this Lions team needs. They were embarrassed by the Packers at home as their defensive struggles continued. This is still a very good Lions team, and this week, they will face a Saints defense that has been slumping. Expect to see the Lions' offense put up a big total in what should be a thrilling shootout in the Big Easy.
The Saints lost a crucial NFC South matchup with the Falcons last weekend. Their defense had another bad game, allowing the Falcons to rush for 228 yards and one touchdown. They failed to generate any pressure and register a sack while hitting Desmond Ridder just once. We think the offense will succeed against a stumbling Detroit defense, but they will have no answer for the Lions’ high-scoring offensive attack.
Lions injury report
Saints injury report
| Bookmaker | Pick | Odds |
| Lions -6.5 | -105 |
| Lions ML | -200 |
| Over 46.5 | -112 |
Miami’s offense had cooled off a bit in November, but that changed when they scored 34 points against a very good Jets defense. Now, they’ll face a Washington defense that is arguably the worst in the NFL, especially against the pass. The team may have rookie running back De’Von Achane back in the lineup, but if they don’t, Raheem Mostert will be in line to have another monster game. The loss of Jaelan Phillips will hurt the defense, but not enough to allow Washington to keep this one close.
This is an awful Commanders team, thanks to their defense. They are allowing 29.2 points per game, the highest mark in the NFL. A big part of that is their inability to stop the pass, which will be a major problem against a Miami offense that leads the league in passing (430.5 YDS/G) and is second in scoring (30.8 PTS/G). The Commanders may find some success against the short-handed Dolphins on Sunday, but not nearly enough to cover for their porous defense.
Dolphins injury report
Commanders injury report
| Bookmaker | Pick | Odds |
| Dolphins -9.5 | -110 |
| Dolphins ML | -450 |
| Over 49.5 | -110 |
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Don’t look now, but the Broncos have won five straight games. Their offense is still middling, but their defense has become the unit Denver fans hoped they would be in 2023. However, they have faced some teams that were slumping. As well as their defense has played, they will be up against a Texans offense that is firing on all cylinders. The Broncos' offense isn’t good enough to score too many points on a young Houston defense, which will cost them the game.
The Texans lost a critical AFC South matchup to the Jags last week, but they are still in the run for an AFC Wildcard spot. Their defense is young and a year or two away from being really good, but their offense has been electric. Rookie CJ Stroud has been one of the best quarterbacks in the league in 2023. He has thrown for 1,466 yards and ten touchdowns over the last four games, completing over 70% of his passes in three. He will find success again this weekend, leading to a Texans win.
Broncos injury report
Texans injury report
| Bookmaker | Pick | Odds |
| Texans -3.5 | -115 |
| Texans ML | -190 |
| Under 47.5 | -112 |
The Chiefs broke out of their November slump in midway through their win against the Raiders last week. However, we still have concerns about their offense. They succeeded against a bad Raiders defense and failed to score more than 21 points against the Eagles, Dolphins, and Broncos the three weeks before. They will now go on the road to face a reinvigorated Packers team with a defense that is thriving. Look for the Chiefs to stumble once again, leading to an upset road loss.
The Packers season has completely turned around in November. They have won three of their four games this month, including an impressive win against the Lions on Thanksgiving. Jordan Love seems to be gaining more confidence with each win, while the Green Bay defense is playing at a very high level. Look for them to find a way to contain Travis Kelce while their offense does just enough to get the win.
Chiefs injury report
Packers injury report
| Bookmaker | Pick | Odds |
| Packers +6 | -110 |
| Packer ML | +220 |
| Under 42.5 | -110 |
Things weren’t going well for the Bengals in 2023, and they are getting worse now that Joe Burrow is out. Jake Browning hasn’t been bad, but he isn’t good enough to compensate for the Bengals' defense. They are one of the worst units in the league, and things will only get more challenging for them now that Burrow won’t be in to lead the offense. That will be a big problem against an 8-3 Jaguars team with many talented skill players on offense.
The Jaguars aren’t one of the NFL’s best teams but they are very good. They’ve won their last two games, including a crucial win over the Texans last week. While their pass defense is weak, their run defense is one of the best in the league. Browning and the Bengals won’t be able to exploit their pass defense, leading to another lopsided loss for Cincinnati.
Bengals injury list
Jaguars injury list
| Bookmaker | Pick | Odds |
| Jaguars -8.5 | -110 |
| Jaguars ML | -400 |
| Under 38 | -110 |
The Niners went into their bye week looking like they were collapsing, but they have been their dominant selves since. They have now won three straight games, all by double digits. Brock Purdy bounced back to become a solid passer once again, while Christian McCaffrey leads the NFL with 939 rushing yards and has scored 14 total touchdowns. The Eagles defense has faltered of late, and that will catch up to them on Sunday, leading to their second loss of the season.
The Eagles have the league’s best record, but there are major red flags around the defense. Their pass defense hasn’t been good all season, but now their run defense is starting to show some cracks. Their offense will struggle against an elite Niners defense, and we just don’t think the Philly defense is good enough to get them the win.
49ers injury list
Eagles injury list
| Bookmaker | Pick | Odds |
| Niners -2.5 | -115 |
| Niners ML | -152 |
| Under 47.5 | -110 |
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