NFL 2023 Week 6 – Odds, Predictions & Picks

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Michael Savio
NFL Week 6
NFL 2023 | Week 6

The NFL season has started with a bang through the first five weeks. We have seen the Niners establish themselves as a powerhouse, the Bengals finally find their offense, and a bunch of bad teams that seem focused on getting Caleb Williams in the 2024 draft. 

Our experts at have been studying each team over the first few weeks, and they are sharing their favorite eight bets heading into Week 6.

Below, we will share their picks, along with odds and insights, to help you win big at NFL betting sites this weekend.

Round 6 Fixtures

Odds provided by DraftKings

GamesAway OddsHome OddsInfo (EST)
Broncos @ Chiefs+410-550Arrowhead Stadium, Thursday 8:15 PM
Ravens@ Titans-198+164Tottenham Hotspur Stadium, Sunday 9:30 AM
Commanders @ Falcons+124-148Mercedes Benz Stadium, Sunday 1:00 PM
Panthers @ Dolphins+550-800Hard Rock Stadium, Sunday 1:00 PM
Vikings @ Bears-142+120Soldier Field, 1:00 PM
49ers @ Browns-325+260Cleveland Browns Stadium, 1:00 PM
Colts @ Jaguars+164-198EverBank Stadium, Sunday 1:00 PM
Saints @ Texans-120+100NRG Stadium, Sunday 1:00 PM
Patriots @ Raiders+140-166Allegiant Stadium, Sunday 4:05 PM
Cardinals @ Rams+260-325SoFi Stadium, Sunday 4:25 PM
Eagles @ Jets-285+230NRG Stadium, Sunday 4:25 PM
Lions @ Buccaneers-166+14Empower Field, 4:25 PM
Giants @ Bills+600-900Highmark Stadium, Sunday 8:20 PM 
Cowboys @ Chargers-130+110SoFi Stadium, Monday 8:15 PM

Broncos vs Chiefs

Denver Broncos Official LogoKansas City Chiefs Official LogoThe Broncos once again proved that they are among the worst teams in the league by losing to the Jets 31-21. Their inability to stop Zach Wilson and the Jets is a very bad omen for this weekend’s matchup with the Chiefs. Denver ranks last in yardage and points allowed per game, and their morale has been broken. Their offense also ranks in the bottom half of the league, making it hard to see them going into Kansas City and being competitive with the Chiefs. 

Kansas City has won their previous four games despite a subpar start from Travis Kelce. The legendary tight end is still dealing with injuries, but the Chiefs backfield has made up for it. They are averaging 123 rushing yards per game and should be able to get at least that much against a Broncos defense that ranks dead last against the run (187.6 YDS/G).

Broncos injury report

  • Frank Clark LB - O
  • D.J. Jones DT    Out - O
  • Greg Dulcich TE - IR
  • Baron Browning LB - PUP

Chiefs injury report

  • Travis Kelce TE - Q
  • Tommy Townsend P - Q
  • George Karlaftis DE - Q


FanDuel Sportsbook ReviewChiefs -10.5-110
DraftKingsChiefs ML-550
BetMGM Sports ReviewOver 47-110

Commanders vs Falcons

Washington Commanders Official LogoAtlanta Falcons Official LogoWashington’s offense has been better than expected in 2023, but their defense is a significant problem. Their struggles were displayed last weekend as they allowed the Bears to score  40 points in a blowout loss at home. The Commanders' defense has allowed opponents to score at least 34 points in their previous four games, which should give a shaky Atlanta offense all it needs to get a win.

Atlanta’s offense is a work in progress, but their defense has been one of the best in the NFC. They looked fantastic last week against a good young Texans team and held their own against the Jags and Lions. Last week’s win also saw Desmond Ridder have the best game of his career, throwing for 329 yards and one touchdown. If he plays anywhere close to that and running back Bijan Robinson bounces back, the Falcons should have no problem running over the Commanders this weekend.

Commanders injury report

  • Darrick Forrest S - IR
  • Jeremy Reaves S - IR
  • Curtis Hodges TE - Q

Falcons injury report

  • Kaleb McGary OT - Q
  • Bud Dupree LB - Q
  • Jonnu Smith TE - Q


FanDuel Sportsbook ReviewFalcons -2.5-110
DraftKingsFalcons ML-148
BetMGM Sports ReviewOver 42.5-110

Vikings vs Bears

Minnesota Vikings Official LogoChicago Bears Official LogoAs good as the Vikings have played on offense (aside from all the fumbles), a lot of their success has been due to Justin Jefferson. He has a third of the team's total receiving yards despite opposing defenses scheming to stop him. Jefferson’s play has helped Minnesota overcome a lackluster backfield, but that won’t be the case Sunday with the receiver heading to the IR. His absence will pressure Minnesota’s backfield and rookie receiver Jordan Addison more.

Don’t look now, but the Bears have posted two impressive offensive games in a row. The success has been due to the connection of Justin Fields and DJ Moore. The two have been an unstoppable duo for the last two weeks, with Moore going for 361 yards and four touchdowns. While the team will be without running back Khalil Herbert, Field's ability to use his legs will cover that as he and Moore pick apart a week of Minnesota secondary. 

Vikings injury report

  • Marcus Davenport LB - Q
  • Justin Jefferson WR - IR
  • Nick Mullens QB - IR
  • Jordan Addison WR - Q
  • Kene Nwangwu RB - IR

Bears injury report

  • Khalil Herbert RB - D
  • Roschon Johnson RB - Q
  • Cole Kmet TE - Q
  • Travis Homer RB - Q
  • Equanimeous St. Brown WR - Q


FanDuel Sportsbook ReviewBears +2.5-105
DraftKingsBears ML+120
BetMGM Sports ReviewUnder 44.5-110

Seahawks vs Bengals

Seattle Seahawks Official LogoCincinnati Bengals Official LogoSeattle’s offense has been fantastic, but their defense has been far less impressive. They were able to bring a terrible Giants offense down in their previous but gave up 27 points to the Panthers the week before. Now that Joe Burrow appears to be healthy, Seattle’s defensive struggles will be exposed in a big way. While Seattle has a ton of talent on offense, they won’t be able to keep up with this improved Bengals offense.

Cincinnati had a brutal start to the season thanks to a calf injury for Joe Burrow. The injury limited the quarterback's mobility and made it hard to plant and pass, but he appeared healthy last week. Burrow threw for 317 yards and three touchdowns in a 34-10 on the road against the Cardinals. We know what Burrow can do when healthy, and Ja’Marr Chase should have no issue getting open against a bad Seattle secondary.

Seahawks injury report

  • Coby Bryant CB - Q
  • Charles Cross OT - Q
  • DK Metcalf WR - Q
  • Jamal Adams S - Q
  • Jordyn Brooks LB - Q

Bengals injury report

  • Akeem Davis-Gaither LB - Q
  • Devin Harper LB - Q
  • Tee Higgins WR - Q
  • Chidobe Awuzie CB - Q


FanDuel Sportsbook ReviewBengals -3-105
DraftKingsBengals ML-162
BetMGM Sports ReviewUnder 45-110

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49ers vs Browns

San Francisco 49ers Official LogoCleveland Browns Official LogoIf there were doubts that the Niners were the best team in the league, they silenced them on Sunday. San Francisco completely overwhelmed the Cowboys on both sides of the ball, leading to a 42-10 win. They have a lot of offensive playmakers that will be able to capitalize on a Browns defense that will be spending a lot of time on the field. Defensively, they should have no problem shutting down a Nick Chubb-less Browns team, especially with Deshaun Watson not playing. 

We believe Cleveland has the best defense in football, but their offense will be a big problem tonight. They have struggled without Nick Chubb, and now Deshaun Watson is battling a rotator cuff injury. Interestingly, the team said Watson was cleared to play in their Week 4 game but chose not to. The Browns were utterly blown out as a result, and we see a similar situation unfolding on Sunday.

49ers injury report

  • Aaron Banks G - Q
  • Elijah Mitchell RB - Q

Browns injury report

  • Joel Bitonio G - Q
  • David Njoku TE - Q
  • Deshaun Watson QB - Q


FanDuel Sportsbook Review49ers -6.5-115
DraftKings49ers ML-325
BetMGM Sports ReviewUnder 37-110

Cardinals vs Rams

Arizona Cardinals Official LogoLos Angeles Rams Official LogoThe Cardinals started the season by impressing many people, but they returned to Earth in their last two games. The biggest reason for the fall-off has been their pass defense, which allowed Brock Purdy to complete 20 of 21 passes and for Joe Burrow to throw for 317 yards and two touchdowns. On the other side of the ball, the Cardinals will be without running back James Conner, who had been a massive part of their offense. His loss means the Rams' defense will focus on Dobbs, leading to a lopsided win for LA.

Last week, the Rams lost to the Eagles, but it wasn’t all bad. It was Cooper Kupp’s first game back from injury, and he looked as good as ever. The veteran had eight catches for 118 yards, while breakout rookie Puka Nacua added another 71 and a touchdown. Kupp and Nacua are a very good receiving duo and running back Kyren Williams appears set to have a breakout season. All three players should find success Sunday en route to a home win. 

Cardinals injury report

  • Jonathan Ledbetter DE - Q
  • James Conner RB - IR
  • Marquise Brown WR - Q
  • Keaontay Ingram RB - Q
  • Elijah Higgins TE - Q

Rams injury report

  • Kevin Dotson G - Q
  • Ernest Jones LB - Q
  • Larrell Murchison DT - Q
  • Ben Skowronek WR - Q
  • Christian Rozeboom LB - Q


FanDuel Sportsbook ReviewRams -7-110
DraftKingsRams ML-325
BetMGM Sports ReviewUnder 48.5-110

Giants vs Bills

New York Giants Official LogoBuffalo Bills Official LogoThis Giants team is both bad and broken. They have been outscored 153-62 this season, scoring more than 16 points just once through the first five weeks. Things will be ugly tonight as they meet a Bills team that is good on both sides of the ball. The Giants lack the playmakers to compete with a team like Buffalo, especially on the road. New York has not covered the spread this season, and we don’t see that trend changing on Sunday night.

The Bills fell victim to a classic trap game last weekend in London, but we expect a big bounce back on Sunday. The Giants have nowhere near the offensive talent of the Jags, and they are playing like their season has already ended. Look for Josh Allen to easily pick apart the Giants' secondary while the Buffalo defense shuts Daniel Jones and the offense down. 

Giants injury list

  • Zack Martin G - Q
  • Micah Parsons LB - Q
  • Tyron Smith OT - Q
  • Peyton Hendershot TE - Q
  • Rico Dowdle RB - Q

Bills injury list

  • Jon Feliciano G - Q
  • Deebo Samuel WR - Q
  • Elijah Mitchell RB - Q
  • Jauan Jennings WR - Q


FanDuel Sportsbook ReviewBills -14-110
DraftKingsBills ML-900
BetMGM Sports ReviewUnder 44.5-110

Cowboys vs Chargers

Dallas Cowboys Official LogoLos Angeles Chargers Official LogoThe Cowboys seem like a very different team after the Niners demolished them on Sunday night. They looked lost on both sides of the ball, showing they were not the powerhouse we believed them to be. We have not seen anything to show us we can trust Dak Prescott and the Dallas pass attack, which they will need to bear LA this weekend. Look for the offense to sputter, as the defense shows just how much they are missing Trevon Diggs.

The Chargers have issues in their secondary, but some of that will be helped by the return of Derwin James Jr this weekend. He is one of the league’s top safeties and will significantly challenge Dak. On the other side of the ball, LA will be getting running back Austin Ekeler back. The veteran has been their most dangerous offensive playmaker, and we expect a big game in his return from injury. 

Cowboys injury list

  • Zayne Anderson S - Q
  • De'Vondre Campbell LB - Q
  • Elgton Jenkins G - Q
  • Luke Musgrave TE - Q
  • Eric Stokes CB - PUP

Chargers injury list

  • Curtis Bolton LB - IR
  • David Long Jr. CB - Q
  • Jimmy Garoppolo QB - Q
  • Nate Hobbs CB - Q


FanDuel Sportsbook ReviewChargers +2.5-112
DraftKingsChargers ML+110
BetMGM Sports ReviewOver 50.5-110

Stay Ahead of the Game with ULB’s Sports Betting Experts!

While betting on the NFL is an exciting experience, finding the right sportsbooks can be a challenge. If you find yourself looking for help in finding an online option to place your wagers this season, we have you covered. Our experts have ranked best NFL betting sites and the best betting apps to help you find a sportsbook that fits your need. If you still aren’t sure,  we’ve got all the sportsbooks reviews for you. 

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